From Idea to Concept – Translation of a Dendritic Tissue Sealant to the Clinic

Tarih: 05.03.2015
Yer: GüneyKampüs Vedat Yerlici Konferans Merkezi 2 Nolu Oda 11:00- 12:30

Prof. Mark W. Grinstaff
Department of Biomedical Engineering and Chemistry, Boston University, Boston, MA & Co-Founder of Four Companies

Dendritic macromolecules are versatile materials for medical applications since the structure, molecular weight, and chemical composition can be precisely controlled. We have reported the synthesis and characterization of polyester, polyester-ether, and polyamide dendrimers and dendrons composed of biocompatible building blocks for medical applications. These dendritic macromolecules can be subsequently crosslinked to form hydrogels using a photochemical or a chemical ligation strategy. The properties – mechanical, swelling, degradation, etc. – of the hydrogels can be tuned by altering the composition, crosslinking chemistry, wt%, generation number and so forth. Corneal wounds were successfully repaired using these hydrogels. These research accomplishments led to the formation of HyperBranch Medical Technology Inc (HBMT) which has successfully developed and commercialized an ocular sealant – OcuSealTM, the first sealant designed for repairing ocular wounds. In this lecture, I will focus on the synthesis, characterization, and in vivo evaluation of dendritic macromolecules as well as the translation of this technology to the clinic.

About the Speaker: Mark W. Grinstaff is the Distinguished Professor of Translational Research and a Professor of Biomedical Engineering, Chemistry, and Materials Science and Engineering, and Medicine at Boston University. Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH

postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher-Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Fellow of the National Academy of Inventors. He is an author or co-author on more than 200 peer-reviewed manuscripts, given more than 275 oral presentations, and an inventor or co-inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings. He is a co-founder of four companies that are commercializing his ideas, and he has three products being sold and used in the clinic. His current research activities involve the synthesis of new macromolecules and amphiphiles, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair.